GEMIO Technologies, Inc. |
One (of several) key aspects of GEMIO's technology
is the fundamentally novel approach to simultaneously consider
time-dependent 3D electromagnetic field solutions and 3D computational
fluid dynamics (CFD) field solutions within a given domain to design
ion-optical instruments. The name
GEMIO is actually an abbreviation for Gas- and ElectroMagnetic Ion
Optics.
This method enables the design of ion sources for biomolecules with spatially and temporally "controlled superposition of electric and gas flow fields" or "electro-pneumatic superposition".
Such configurations belong to a new class of electro-pneumatic ion optical devices in which so called electro-pneumatic elements (EPEs) act as electrodes AND as aerodynamic structures and in which collision frequencies, momentum transfer, and energy transfer between gas molecules and ions vary spatially in a controlled fashion.
The ion dynamics resulting from the superposition of non-trivial electric and pneumatic vector fields can no longer be measured, imagined, or analytically calculated. Advanced numerical simulations are the only way to understand and design realistic 3D electro-pneumatic configurations. Devices based on this principle provide unprecedented control over the dynamics and temperatures of ion ensembles which is of critical importance for highly sensitive ion sources for biological macromolecules.
Ultimately, advanced ion sources for biomolecules are one of the most important technical components to enable reliable biomarker discovery with sufficient sensitivity and specificity leading to early stage molecular detection of diseases such as cancer.
On the origin of MALDI and ESI ionization see also:
http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/tanaka-lecture.html
http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/fenn-lecture.html
This method enables the design of ion sources for biomolecules with spatially and temporally "controlled superposition of electric and gas flow fields" or "electro-pneumatic superposition".
Such configurations belong to a new class of electro-pneumatic ion optical devices in which so called electro-pneumatic elements (EPEs) act as electrodes AND as aerodynamic structures and in which collision frequencies, momentum transfer, and energy transfer between gas molecules and ions vary spatially in a controlled fashion.
The ion dynamics resulting from the superposition of non-trivial electric and pneumatic vector fields can no longer be measured, imagined, or analytically calculated. Advanced numerical simulations are the only way to understand and design realistic 3D electro-pneumatic configurations. Devices based on this principle provide unprecedented control over the dynamics and temperatures of ion ensembles which is of critical importance for highly sensitive ion sources for biological macromolecules.
Ultimately, advanced ion sources for biomolecules are one of the most important technical components to enable reliable biomarker discovery with sufficient sensitivity and specificity leading to early stage molecular detection of diseases such as cancer.
On the origin of MALDI and ESI ionization see also:
http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/tanaka-lecture.html
http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/fenn-lecture.html