One (of several) key aspects of GEMIO's technology is the fundamentally novel approach to simultaneously consider time-dependent 3D electromagnetic field solutions and 3D computational fluid dynamics (CFD) field solutions within a given domain. The name GEMIO is actually an abbreviation for Gas- and ElectroMagnetic Ion Optics.
This method enables the design of ion sources for biomolecules with spatially and temporally "controlled superposition of electric and gas flow fields" or "electro-pneumatic superposition".
Such configurations belong to a new class of electro-pneumatic ion optical devices in which so called electro-pneumatic elements (EPEs) act as electrodes AND as aerodynamic structures and in which collision frequencies, momentum transfer, and energy transfer between gas molecules and ions vary spatially in a controlled fashion.
The ion dynamics resulting from the superposition of non-trivial electric and pneumatic vector fields can no longer be measured, imagined, or analytically calculated. Advanced numerical simulations are the only way to understand and design realistic 3D electro-pneumatic configurations.
Devices based on this principle provide unprecedented control over the dynamics and temperatures of ion ensembles which is of critical importance for highly sensitive ion sources for biological macromolecules.
Ultimately, advanced ion sources for biomolecules are one of the most important technical components to enable reliable biomarker discovery with sufficient sensitivity and specificity leading to early stage molecular detection of diseases such as cancer.
On the origin of the ionization method(s) see also:
http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/tanaka-lecture.html
http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/fenn-lecture.html
Some aspects of the technology utilized by GEMIO Technologies, Inc. have been
described in these publications and presentations:
[1] A. Hieke: "Predicting Charged Particle Trajectories",
ANSYS Advantage Magazine, Volume II, Issue 2, 2008, pp. 31-33
ansys-advantage/02-electromagnetics.pdf
[2] A. Hieke: "Advanced ion sources for biomolecules",
Presentation at the TechConnect Summit during the NSTI
Nanotechnology Conference & Trade Show
Santa Clara, California, May 20-24, 2007
http://www.techconnect.org/Summit2007/program/showabstract.html?absno=11086
http://www.nsti.org/Nanotech2007
[3] Andreas Hieke: "From Science to Profit"
The NanoBusiness Alliance Conference
May 17-19, 2006, New York, NY
[4] Andreas Hieke: Corporate Presentation
at NSTI Nanotech Ventures Program
2006 NSTI Nanotechnology Conference & Trade Show
May 8-9, 2006, Boston, MA
www.nsti.org/Nanotech2006/Development/ventures.html#TU53.1
www.nsti.org/Nanotech2006/showabstract.html?absno=21070
[5] Andreas Hieke: "From Physics to Medicine (via nano !?)"
at
"Challenges Facing Early-Stage Nanotech Start-ups in 2006"
January 10th, 2006; Menlo Park, CA
http://www.nanoscienceexchange.org/invite11006.html
[6] Andreas Hieke: "Simulations of ion population
dynamics in ion
sources for biological macromolecules"
13th Foresight Conference on Advanced
Nanotechnology
Oct. 22-27, 2005; San Francisco,CA
http://www.foresight.org/conference2005/program.html
[7] A. Hieke, S. R. Weinberger: "Ion Cooling and Transmission
Performance of an Advanced MALDI-Ion
Source based on
3D Electric-Pneumatic Ion Dynamics Simulations"
The 32nd FACSS and 51st ICASS
Meeting
(Federation of Analytical Chemistry and Spectroscopy Societies)
October 9 - 13, 2005; Quebec
City, Canada
[8] A. Hieke: "Monte Carlo Ion Dynamics Simulations - Implementational
Challenges and Results",
2005 Western Region ANSYS Technical
Conference Sept. 15-16, 2005; Santa Clara, CA
[9] A. Hieke, S. R.Weinberger:
"An Advanced Laser Desorption
Ionization Ion Source with Controlled Superposition of Electric
and Pneumatic Fields"
53rd ASMS Conference on Mass Spectrometry and Allied Topics
June
5 - 9 2005, San Antonio, TX
full paper
[10] A. Hieke: "Ion Sources for Biomolecules with controlled
Superposition of Electric and Pneumatic Fields"
2005 NSTI Nanotechnology Conference and Trade Show
May 8-12, 2005, Anaheim, CA
http://www.nsti.org/Nanotech2005/showabstract.html?absno=1056.00
full paper
[11] A. Hieke: "Ion Dynamics in Electro-Pneumatic Fields - a Key to
Modern Biotechnology", Ansys
Solutions Magazine, Spring 2005,
pp.13-17
http://www.ansys.com/assets/testimonials/ion-dynamics.pdf
[12] A. Hieke: "Electro-Pneumatic Ion Optics - Simulations and
Preliminary Experiments", 22nd CAD-FEM Users´ Meeting &
International Congress on FEM-Technology,
November 10-12, 2004, Dresden, Germany
[13] A. Hieke: "Simulations of ion population dynamics
dominated by
discrete collision events in rarified gases in the presence of
electromagnetic fields",
International Conference on Transport
Phenomena in Micro and Nanodevices
Oct. 17-21 2004, Kona Coast,
Hawaii
http://www.engconfintl.org/pastconf/4atpre.pdf
[14] A. Hieke: "3D electro-pneumatic Monte Carlo simulations of ion
trajectories and temperatures
during RF quadrupole injection in
the presence of gas flow fields"
52nd ASMS Conference on Mass
Spectrometry and Allied Topics
May 23 - 27 2004 Nashville, TN
full paper
[15] A. Hieke: "Development of an Advanced Simulation System for the
Analysis of Particle Dynamics in LASER based Protein Ion Sources",
2004 Nanotechnology Conference and Trade Show Nanotech 2004
March 7-11, 2004 Boston, MA
http://www.nsti.org/procs/Nanotech2004v1/5/W21.05
full paper
[16] A. Hieke: "Theoretical and Implementational Aspects of an
Advanced 3D Gas and Electromagnetic
Ion Optical Simulator
Interfacing with ANSYS Multiphysics"
21st CAD-FEM Users´ Meeting &
International Congress On
FEM-Technology, Nov. 12-14 2003, Potsdam, Germany
[17]
A. Hieke: "GEMIOS - a 64-Bit multi-physics Gas and Electromagnetic
Ion Optical Simulator", 51st ASMS
Conference on Mass
Spectrometry and Allied Topics, June 8 - 12 2003, Montreal, Canada